Vascular Research
Scope and Challenges
Each year more than 17 million persons die from cardiovascular diseases – this is one third of the global death toll. Atherosclerosis of the coronary or peripheral arteries are the main predictors of future cardiovascular events (1,2). Thrombotic events may not only occur in arteries, but also in veins (3), which may lead to fatal pulmonary embolism (4,5). It is estimated that more than 100,000 deep vein thromboses occur each year in Germany. The principal objective of vascular medicine is to prevent and treat both arterial as well as venous disorders in order to avoid severe complications. Here, antithrombotic therapy plays a central role.
Targeted, focused and successful
The starting point for vascular research is the identification of an important medical need on the one hand, and the vision for potential benefits of an innovation on the other. Effective and efficient vascular research merges the two and thus defines the way forward for the optimal use of innovations for the best possible benefit of the vascular patients.
Professor Bauersachs brings these two preconditions together at VASC - Center for Vascular Research. He combines his extensive experience in clinical practice as a vascular physician with his long-term competence from his numerous scientific studies.
Vascular Research - Examples of Problem-oriented Studies, conducted by Professor Bauersachs include:
- Medical Need: Vulnerable Patient Populations (renal insufficiency, elderly patients, fragile patients)
> Studies to Optimize the Use of Anticoagulants in these Risk Groups (CERTIFY (6,7)), (EINSTEIN-Studies) (8); Guidance for the treatment of elderly patients (9). - Medical Need: Pregnant Women at Increased Risk of Thrombosis
> Largest Prospective Study on the Stratified Use of Heparin (EThIG-Study (10)) - Medical Need: Insufficient Evidence for Patients with Superficial Vein Thrombosis
> First Large Prospective, Placebo-controlled Trial (CALISTO (11)); Study in High-Risk Patients (SURPRISE (12)); Analyses of the Current Management in the Real World (INSIGHTS (13)) - Medical Need: Dialysis Patients Requiring Anticoagulation
> First German Controlled Trial in Dialysis Patients with DOACs (AXADIA (14)) - Medical Need: Patients with Cancer Associated Thrombosis (CAT)
> Studies to Improve Anticoagulation in CAT (CATCH (15,16))
> Use of Oral Anticoagulants in CAT (17,18) - Medical Need: Improve “Established” Modes of Anticoagulation
> Studies to Evaluate New Anticoagulant Agents (EINSTEIN-DVT (19)) - Medical Need: Decrease Bleeding Risk Associated with Extended Anticoagulation
> Studies for Extended Anticoagulation with a Lower Risk of Bleeding (EINSTEIN-EXTENSION (19), EINSTEIN-CHOICE (20)) - Medical Need: Establish Effective and Safe Antithrombotic Therapy after Revascularization
> Largest Prospective Study in Revascularized PAD patients (VOYAGER (21)) - Medical Need: Overcoming Inherent Risk of Bleeding with Anticoagulants
> Development of new Anticoagulants (Factor XI Inhibitors) (FOXTROT (22))
Education and Teaching
Fresh Concepts for Vascular Medicine
New results and observations from evidence-based research frequently are communicated to practicing physicians in a rather abstract way without considering the actual real-world needs of their environments. Thus, dissemination of new evidence into everyday practical clinical work often is unsatisfactory, and the acceptance of medical education programs commonly is low, as is participation and motivation.
The underlying reason for this is that educational material, content and methodology are derived from perspective of the “sender” rather than from the different situation and needs of the “receivers”. In addition, communication to young doctors is increasingly challenging due to the rapidly changing pathways and modalities of the younger generation, including faster communication, more rapid change of focuses and shorter attention span for one single topic. Since there is an enormous variation with respect to age, clinical setting, education, medical specialty and with a variety of topics at stake, rarely does this “one size fits all” reach such diverse addressees.
Therefore educational events, materials, publications and communication tools have to be specifically developed for the individual target group; this has always been the focus and competency of VASC – tailoring educational content to specific target groups.
Professor Bauersachs has a long-term experience ranging from small to very large educational events, encompassing a wide spectrum of formats: This includes use of various media and formats, as well as adaptation to different professions, specialties, knowledge and clinical experience - tailored to needs and expectations of the participants.
A core factor of his successful educational activities is credibility, appreciation, transparency, practicability and interactivity, resulting in better understanding and further advancement of knowledge and expertise. Concise knowledge that incorporates the key issues is important for everyday practice and ultimately for the benefit of the patients.
Bauersachs´ sincere and transparent communication tailored to the needs of patients and doctors is always on equal footing to his audience by being encouraging vital, successful and – simply fun!
Lectures
Workshops
Educational Material / Constructive Feedback and Evaluation
Consulting
Consulting in Vascular Research
Through the combination of many years of practical medical work and profound experience from vascular research, Professor Bauersachs can ideally identify, evaluate and assess the chances of success of innovative approaches. In all phases of clinical development, these early assessments are indispensable and provide a solid basis for identifying specific research questions for scientific studies. Critical assessment is particularly important with regard to study design, statistics, practicability, likelihood of success, feasibility, future relevance, identification of potential limitations, and overcoming these challenges at the outset and during the course of the studies. New scientific concepts are critically and constructively supported by VASC, the Centre for Vascular Research. Project and research ideas are developed and coordinated, publications prepared and study results are successfully published.
Professor Bauersachs´ thoughtful, unbiased, honest, realistic and practical assessment is sought for in the planning of studies and many advisory boards. He identifies pitfalls, errors to be avoided, and then secures the project. His interdisciplinary approach and his interlinking work between different disciplines, between care levels, theoretical and clinical researchers, sponsors and study centers, patients and doctors are particularly appreciated. Professor Bauersachs is a conductive bridge builder between these vastly different poles, functioning as translator and mediator. In order to establish a common basis on an equal footing is an important prerequisite for joint success.
Transfer of Theoretical Knowledge into Practical Action
A central concern of Professor Bauersachs has always been to derive clear, practical and pragmatic solutions for complex clinical situations. In this way, making existing evidence available to clinicians and physicians in practice alike, in order to support their everyday work for the best benefit of the vascular patients.
Successful Implementations of Existing Evidence Supported by Professor Bauersachs Include:
- Collaboration with Guidelines, e.g. S3 Guidelines on Hormonal Contraception; ESC Consensus on Thrombosis Therapy, ESC Consensus on Antithrombotic Therapy in PAD; ESVS Clinical Practice Guidelines on Thrombosis Management) ((23,24)21,22)
- Interdisciplinary Statement Document on Efficient Thrombophilia Screening before First Pill Prescription (25)
- Defining Requirements for Outpatient Treatment of Venous Thromboembolism (25)(26) (26)(27)
- Making Periinterventional Management more Effective and Safer (28)(29-32) and Bridging-Checklist (31)
- Development of Practical Recommendations for Deciding on the Duration of Anticoagulation: "Thrombosis traffic light system" (33)
- Development of Practical Recommendations for the Choice of Anticoagulation in Cancer Patients: DOAK matrix (CAT)(17,34)(24)
- Risk of Thrombosis in Pregnancy, Risk of Miscarriage (35-40)
- Management of Distal Vein Thrombosis (41)
- Anticoagulation in Antiphospholipid Syndrome (42)
- Anticoagulation in in COVID-19 (43)
“Transparent communication on equal footing is vital- whether it is to patients or colleagues - That's important to me.”
Prof. Dr. Med. Rupert Bauersachs
Mediator and Visionary
Professor Bauersachs studied medicine from 1977 to 1983 at the Ludwig-Maximilians-University of Munich and the Technical University of Munich, and in 1981 at Oxford University Medical School. In 1984 he received his Medical Doctorate. From 1984 to 1985 he was a research assistant at the Institute of Pharmacology at the Technical University of Munich and from 1985 to 1987 he was a Research Fellow of the American Heart Association at the Dept. of Physiology and Biophysics at the University of Southern California, Los Angeles. From 1987 to 1993 he completed his specialist training in Internal Medicine at the Klinikum München-Bogenhausen and from 1993 to 1999 he continued his training at the Universities of Frankfurt and Mainz and received his board certifications as an Angiologist, Diabetologist, Phlebologist and Hemostaseologist and Aviation Medicine. In 1999, he completed his postdoctoral lecturing qualification with his research on ischemia and reperfusion injury and obtained the teaching certification for Internal Medicine and Angiology at the Goethe University of Frankfurt. In 1999 he was awarded a Fellowship of the International Union of Angiology.
From 1999 to 2003, Professor Bauersachs became acting director of the Department of Vascular Medicine at the Goethe University Frankfurt, Main and in 2000 co-founded the first German University Vascular Center at the University of Frankfurt. In 2003 he was appointed director of the Medical Department of Angiology at the Klinikum Darmstadt and was co-founder of the Vascular Center Darmstadt. In 2004 Prof. Bauersachs received the professorship at the University of Frankfurt am Main and in 2012 became Visiting Professor for Vulnerable Individuals and Populations – VIP at the Center for Thrombosis and Hemostasis (CTH) at the University of Mainz.
He is the scientific director of the Thrombosis Action Alliance, which he co-initiated in 2014 and which organizes the yearly World Thrombosis Day[4] in Germany.
In 2020, Professor Bauersachs founded VASC, Center for Vascular Research.
Since 2021 he working as a Vascular Physician and Hemostaseologist at the Cardioangiologic Center Bethanien, CCB in Frankfurt , Germany.
Publications
Vascular Medicine
Here you can read and download the latest published articles:
PubMed.gov, Prof. Dr. med. Rupert Bauersachs
researchgate.net, Prof. Dr. med. Rupert Bauersachs
Contact
Get in Touch...
Do you have questions or a specific concern? Write Professor Bauersachs or call him directly.